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Zoloft is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Zoloft affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms Zoloft is an antidepressant drug of the group SSRI. It affects the chemicals that cause depression, panic, anxiety, or obsessive-compulsive symptoms. It is used for treatment of depression, OCD, panic and anxiety disorder, PTSD, and PMDD. However, it may be used for other medical treatments as well. Important information about Zoloft Zoloft should not be administered in combination with pimozide (Orap) or a monomine oxidase inhibitor (MAOI). At least two weeks should pass after stopping an MAOI prior to taking Zoloft. And this should be the case the other way around as well. As it is common with all the antidepressant drugs, the patient (more common for patients younger than 24 years) may experience suicidal thoughts when taking Zoloft. The FDA has approved this drug for treating children with OCD but not for depression. The first 3 months of treatment must be closely monitored by the physician. If you experience any symptoms such as mood swings, anxiousness, panicky behavior, sleep deprivation, increased impulsiveness, irritation, aggressiveness, restlessness, suicidal thoughts etc. consult your physician immediately. This drug may be the cause of serious of life-threatening lung problems in newborn babies. However, pregnant women must consult their doctors before stopping Zoloft to avoid further complications.